干细胞的生物力学研究

吕东媛; 周吕文; 龙勉

doi:10.6052/1000-0992-16-041

干细胞的生物力学研究

doi: 10.6052/1000-0992-16-041

中国科学院力学研究所微重力重点实验室/工程化构建与力学生物学北京市重点实验室, 北京100190

详细信息

作者简介:
龙勉, 工学博士, 中科院力学所研究员, 博士生导师. 1995 年晋升为教授,2000 年入选中科院"百人计划", 2002 年获国家杰出青年基金, 2004 年入选"新世纪百千万人才工程国家级人选". 先后任世界生物力学理事会(WCB) 执委、国际生物流变学学会(ISB) 理事、世界华人生物医学工程协会(WACBE) 理事、中国力学学会副理事长等, 担任C ell. Mol. Bioengi.,Biophys. Rep. 副主编及相关杂志编委. 研究兴趣为蛋白质间相互作用与组装动力学、细胞-亚细胞力学-生物学耦合、空间细胞-分子生物力学工程. 在Nature, Biomaterials, J Immunol. 等杂志发表学术论文124篇. 获教育部首届青年教师奖、中国力学学会青年科技奖等. mlong@imech.ac.cn

中图分类号: R 318.01
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出版历程
- 收稿日期: 2016-11-15
- 网络出版日期: 2017-01-24
- 刊出日期: 2017-02-24

Biomechanics of stem cells

Key Laboratory of Microgravity (National Microgravity Laboratory) and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China

摘要

摘要: 干细胞生物力学作为生物力学的重要分支和前沿学科, 近年来在力学-生物学、力学-化学耦合等方面取得了重大进展, 已成为生物力学乃至生物医学工程最活跃的领域之一, 并对发育生物学、干细胞生物学、组织修复、再生医学等相关领域产生重要影响. 干细胞具有独特的力学性质, 可感知、传递、转导和响应生理力学微环境的改变, 从而调控干细胞的生长、分化等功能, 体现出典型的力学-生物学耦合特征. 本文将对干细胞的力学性质与细胞力学模型、在体力学环境对干细胞生长和分化的影响、干细胞对外界力学刺激的响应等方面加以综述.
- 干细胞 /
- 生物力学 /
- 力学-生物学耦合 /
- 力学微环境 /
- 信号传递与转导
Abstract: As an important branch of biomechanics, stem cell biomechanics has made great progress in mechano-biological, mechano-chemical coupling, and other related felds in recent years. It has become one of the most active felds in biomechanics and biomedical engineering, and made signifcant impacts on the areas of stem cell biology, tissue repair, regenerative medicine, and so on. Stem cells have unique mechanical properties, which can sense, transmit, transduce and respond to changes in physiological and mechanical microen-vironment, thus regulating the function of stem cell growth and differentiation, showing a typical mechano-biological coupling characteristics. This paper reviews the mechanical properties of stem cells and cell mechanics models, the effects of in vivo mechanical mi-croenvironment on stem cell growth and differentiation, and the responses of stem cells to external mechanical stimuli.
- stem cell /
- biomechanics /
- mechano-biological coupling /
- mechanical microenvi-ronment /
- signal transmission and transduction

HTML全文

图 1 典型的4种连续介质细胞模型.(a)线弹性固体模型(b)黏弹性固体模型(c)牛顿液滴模型,(d)复合液滴模型

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图 2 典型的3种细胞结构模型.(a)开孔泡沫模型,(b)索网模型(c)六杆张力整合模型

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图 3 组织微观力学影响干细胞分化并与细胞核内富含的骨架蛋白lamins相关( Swift et al. 2013)

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图 4 线粒体动力学通过调控核转录程序影响干细胞命运( Khacho et al. 2016)

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图 5 组织形态建成中的力学因素( Patwari & Lee 2008)

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图 6 干细胞"壁龛"中的力学作用模式( Conway & Schaffer 2012)

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图 7 硬度范围与相应的组织类型( Buxboim et al. 2010)

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图 8 基底硬度耦合拓扑结构对MSC的影响.(a)MSC在不同基底上的形态、细胞骨架及黏附斑蛋白的表达,(b)结构模式示意图

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图 9 不同基底硬度耦合拓扑结构基底对胚胎干细胞干性的影响(Lü et al. 2014)

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图 10 细胞力学信号转导的媒介( Ingber 2006)

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图 11 黏着斑复合物结构示意图( Mitra et al. 2005)

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图 12 力学组学概念示意图

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map

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