Abstract: In order to investigate the possibility ofrealizing the high-speed flight with supersonic airplanes, rockets and　guided missiles, Professor Hsue-Shen Tsien has made great contributions　to research and development in the fields of Aerodynamics, Solid　Mechanics, Flight Mechanics; and has founded several new branches in　Engineering Sciences, i.e., Jet Propulsion Science & Technology,Engineering Cybernetics and Physical Mechanics, etc. Furthermore, he has　made systematic exposition of the intension and development orientation　for Modern Mechanics as well as Engineering Sciences. In this paper, his　brilliant research work is introduced, and his foresighted scientific　thought is explored and discussed tentatively.