In order to investigate the possibility ofrealizing the high-speed flight with supersonic airplanes, rockets and guided missiles, Professor Hsue-Shen Tsien has made great contributions to research and development in the fields of Aerodynamics, Solid Mechanics, Flight Mechanics; and has founded several new branches in Engineering Sciences, i.e., Jet Propulsion Science & Technology,Engineering Cybernetics and Physical Mechanics, etc. Furthermore, he has made systematic exposition of the intension and development orientation for Modern Mechanics as well as Engineering Sciences. In this paper, his brilliant research work is introduced, and his foresighted scientific thought is explored and discussed tentatively.