Volume 42 Issue 3
May  2012
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Article Contents
MA Guojun, WU Chengwei. A REVIEW ON MECHANICS PROBLEMS IN MICRONEEDLE DESIGN AND PENETRATING PROCESS[J]. Advances in Mechanics, 2012, 42(3): 314-331. doi: 10.6052/1000-0992/11-155
Citation: MA Guojun, WU Chengwei. A REVIEW ON MECHANICS PROBLEMS IN MICRONEEDLE DESIGN AND PENETRATING PROCESS[J]. Advances in Mechanics, 2012, 42(3): 314-331. doi: 10.6052/1000-0992/11-155

A REVIEW ON MECHANICS PROBLEMS IN MICRONEEDLE DESIGN AND PENETRATING PROCESS

doi: 10.6052/1000-0992/11-155
Funds:  The project was supported by the National Natural Foundation of China (10972050, 10802019, 10925209).
More Information
  • Corresponding author: WU Chengwei
  • Received Date: 2011-11-16
  • Rev Recd Date: 2012-01-19
  • Publish Date: 2012-05-25
  • Recently, a novel technology known as microneedles have received much attention because they can be used for transdermal drug delivery and blood sampling in a painless and minimally invasive manner. However, there are still some problems that restrict its practical applications in clinical therapies. In this review, we first give a presentation of this novel technology, including its development history and development trends, and then discuss the existing mechanics problems. First, researches on the mechanics problems of microneedle are elaborated, including insertion force, structure strength, stiffness and drug deliver via microneedle. And then, we present new developments in the study on biomicroneedles and bionicmicroneedles, and describe the micronanostructures and mechanics principle of the biomicroneedle using a super small penetrating force, and finally discuss the inspirations provided by the biomicroneedle for the improvement of artificial microneedles design.

     

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