Abstract: Hypersonic technical project "Hyper-X" not only makes use of the hypersonic flight within the atmosphere and verifies the core principles of supersonic combustion and airframe integrated propulsion design, but also promotes the sustainable development of the worldwide hypersonic technology. This paper analyzes the research progress of Hyper-X in fundamental and applied hypersonic technologies, especially those combining theoretical computations and ground tests with flight tests to solve major aerodynamic problems systematically. The ideas and methods of Hyper-X aerodynamic researches are reviewed on the level of methodology, and the essence of the methodology includes such as the decomposition and integration, the progressive and transition, the knowledge and standards, the verification and validation. Some applications of the methodology in solving key aerodynamic problems arising from hypersonic airbreathing vehicle are also discussed.