Abstract: The light-weighted sandwich structures are widely used in the field of energy absorption. The dynamic response of the spherical sandwich structure under inner blast loading is analyzed by means of numerical simulation. It is found that the inner wall of the spherical sandwich structure plays a key role in energy dissipation, which is different to that of the flat or curved sandwich plate. Compared with homogeneous spherical shell of the same mass, the core of spherical sandwich structure can effectively reduce the deformation and stress level of the outer wall. In addition, the influence of geometric size on energy absorption of spherical sandwich structure is obtained by theoretical analysis. Finally, it is pointed out that in the design of the explosive vessel, if the energy consumption of the inner wall of the spherical sandwich structure is fully utilized, the anti-explosive equivalent can be remarkably improved.