Abstract: The rapid development of society has put forward higher requirements for the safe, stable and energy-saving operation of the steam pipeline network, and it is necessary to more accurately grasp the dynamic operation law of the steam pipeline network. In this paper, a simulation model of hydrothermal calculation of the steam pipeline network is established, the flow resistance coefficient of the pipe section is corrected by the combination of genetic algorithm and pipeline network mechanism, and the dynamic response of pipeline pressure and flow corresponding to the change of different pipeline parameters is explored by the proposed simulation calculation method. The experimental results show that the pressure change of the pipeline is closely related to the change of the pipeline flow, and the parameters of pipe length and diameter are closely related to the dynamic response characteristics of the pipeline. Compared with the traditional computational fluid dynamics (CFD) algorithms, the simulation calculation method proposed in this paper has good calculation accuracy and fast calculation speed in calculating the dynamic response results of different pipeline parameters of the pipeline network, which is suitable for the simulation research and dynamic response process research and lightweight algorithm integration of the steam pipeline network under different working conditions, which provides an effective means to deal with the emergency situation of the pipeline network and improves the operation and scheduling safety of the pipeline network.