Abstract: When the computational fluid dynamics discrete element method (CFD-DEM) is used for solid-liquid two-phase coupling analysis, the selection of particle calculation time step directly affects the accuracy and efficiency of the coupling calculation. For this reason, each target particle is selected as the research object, and interpolation function is introduced to calculate the motion displacement of the time step, and a variable spatial search grid is constructed. An improved particle collision search algorithm (modified discrete element method, MDEM) was proposed by selecting possible collision particles to build a search list and using reverse search Method to judge collision particles. The algorithm in particle group and fluid coupling calculation, the particle counting the initial time step selection particle collision time without limit, realization of automatic adjustment and correction by large step, calculated by the real-time update of fluid particles and fluid coupling conditions, time step, the granular computing time step selection, as a result of low computational efficiency, selection is too large too small to solve the problem of false negatives, particle collision of particles and fluid coupling numerical simulation provides a effective calculation method. Through the numerical simulation of two particles and multiple particles, the relative errors of the collision forces, collision positions and times between particles obtained are all less than 2% compared with the theoretical calculation results. Compared with the traditional DEM collision search algorithm, the three calculation time steps selected do not affect the calculation accuracy, and the calculation efficiency is higher. Through the coupling numerical simulation of multiple particles and fluid, using the traditional CFD-DEM method, the precise solution can be obtained only when the particle calculation time step is 10^-6 s or smaller, while the precise solution can be obtained by using the proposed method to take 10^-4 s, which avoids the problem of missed decision caused by particle collision with the increase of time step, and the calculation time is reduced by 16.7%.