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中文核心期刊

声场操控微颗粒图案化实验研究

EXPERIMENTAL STUDY ON THE EFFICIENCY OF MICROPARTICLES PATTERNING MANIPULATED BY ACOUSTIC FIELD

  • 摘要: 体声波(bulk acoustic wave, BAW)作为一种典型的声场操控方法, 能够实现微颗粒三维方向上的直接排列, 并因其优良的生物兼容性, 在微小生物目标图案化排列方面展示出巨大的应用潜力. 在组织工程和生物3D打印等相关应用领域中, 微颗粒图案化排列的效率是最终成型质量的关键因素. 尽管已有对图案化排列过程中微粒运动的理论描述, 但由于微尺度下无法实施高精度测量, 难以构建准确可靠的仿真模型, 因此影响图案化排列效率的具体因素尚不明确. 为了探究影响图案化排列效率的主要因素及其特征, 本研究设计并构建了一套可视化实验平台. 通过显微视觉系统, 精确观察了BAW作用下微颗粒的运动行为以及单个微颗粒的状态变化, 分析了压电陶瓷换能器驱动电压、悬浮液浓度、颗粒尺寸和液体黏度对排列时间的影响规律. 结果表明, 在特定范围内, 微球悬浮液浓度的增加会导致排列时间略微延长, 然而这种差异并不显著; 对于直径范围在10 ~ 100 μm之间的微球, 其尺寸的增大有助于提高排列效率; 相较于其他参数, 液体黏度对排列效率的影响最为显著. 本研究为基于BAW实现微颗粒图案化研究及相关应用提供了重要数据和设计指导, 有助于推动生物医学和材料科学等相关领域的发展.

     

    Abstract: Bulk acoustic wave (BAW), as a typical acoustic field manipulation method, enables direct alignment of microparticles in three-dimensional directions with excellent biocompatibility, and shows a broad application prospect in patterning arrangement of tiny biological targets. For tissue engineering, bio-3D printing and other related applications, the efficiency enhancement of microparticle patterning arrangement is a key factor for the final quality. Although theoretical descriptions of particle motion during the patterning process are available, the factors affecting the patterning efficiency are still unclear due to the inability to implement high-precision measurements at the microscale and the difficulty of constructing accurate and reliable simulation models. In order to investigate the main factors affecting the patterning efficiency and their characteristics, a set of visualization experimental platform was designed and constructed, and the motion behaviours of microparticles under the action of BAW and the state changes of individual microparticles were precisely observed by using a microscopic vision system, and the effects of the piezoelectric ceramic transducer driving voltage, suspension concentration, particle size, and liquid viscosity on the patterning time were analysed. This integrated approach not only advances our understanding of the underlying mechanisms governing microparticle patterning but also provides valuable insights for optimizing patterning processes in diverse applications. The results show that, in a specific range, the increase of microsphere suspension concentration leads to a slight prolongation of the patterning time, however, this difference is not significant; for microspheres with diameters between 10 μm and 100 μm, the increase of their diameters contributes to the enhancement of the patterning efficiency; and the liquid viscosity has the most significant effect on the patterning efficiency compared to other parameters. This study provides important data and design guidance for the study of BAW-based realisation of microparticle patterning and related applications, which can help to promote the development of biomedical, materials science and other related fields.

     

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